Myocardial reperfusion injury: looking beyond primary PCI
نویسندگان
چکیده
منابع مشابه
Myocardial reperfusion injury: looking beyond primary PCI.
Coronary heart disease (CHD) is the leading cause of death and disability in Europe. For patients presenting with an acute ST-segment elevation myocardial infarction (STEMI), timely myocardial reperfusion using either thrombolytic therapy or primary percutaneous coronary intervention (PPCI) is the most effective therapy for limiting myocardial infarct (MI) size, preserving left-ventricular syst...
متن کاملLooking Beyond Reperfusion
The root cause of acute myocardial infarction (AMI) was postulated way back in in 1912 by James Herrick who proposed it to be thrombotic occlusion of the coronary artery [1,2]. This hypothesis prioritized thrombolytic agents into the line of treatment which could remove thrombotic occlusion, restore blood supply to myocardium and prevent or limit the extent of myocardial damage. Hume et al in 1...
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Around the world, and especially in the Western Society, cardiovascular diseases remain one of the leading causes of death.(1) Within the broad range of cardiovas-cular diseases, the proportional burden of ischemic heart disease is especially high within the Middle East, North America, Australia, and the majority of Europe.(2) In the Netherlands, cardiovascular diseases have been the leading ca...
متن کاملManagement of myocardial infarction: looking beyond efficacy.
Over the last two decades, management of acute myocardial infarction (MI) has shifted from a “wait and watch” strategy to an increasingly aggressive strategy of restoring and maintaining (e.g., thrombolytics, antiplatelet agents) early patency to the infarct-related vessel and to other approaches that directly protect the myocardium (e.g., beta-blockers, angiotensin-converting enzyme inhibitors...
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Myocardial I-R injury contributes to adverse cardiovascular outcomes after cardiac surgery. The pathogenesis of I-R injury is complex and involves the activation, coordination, and amplification of several systemic and local proinflammatory pathways (Fig. 4). Treatment and prevention of perioperative morbidity associated with myocardial I-R will ultimately require a multifocal approach. Combini...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2013
ISSN: 1522-9645,0195-668X
DOI: 10.1093/eurheartj/eht090